The FOXP3 gene is a critical transcription factor on the X chromosome that acts as the "master regulator" for the development and function of regulatory T cells (Tregs). It drives immune tolerance, preventing autoimmunity by suppressing excessive immune responses. Mutations in FOXP3 cause IPEX syndrome (immune dysregulation, polyendocrinopathy, enteropathy, X-linked), a severe autoimmune condition.
Purity: Greater than 85% as determined by SDS-PAGE.
Target Names: FOXP3
Uniprot No.: Q9BZS1
Alternative Name: Scurfin
Species: Homo sapiens (Human)
Expression system: E.coli
Expression Region: 1-417aa
Mol. Weight: 53.2 kDa
Protein Length: Full Length of Mature Protein
Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged
Target Protein Sequence:
MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKR