NRicher™ Mx (beads for enrichment of low abundance proteomes) - 50 reactions

General Enrichment for All Biofluids and Tissue Lysates

Consumable chemically derived beads, species agnostic as they are not derived from antibodies Enrich low abundance proteomes from any source, from sera/plasma to cell lysates from both animals and humans, >90% Albumin removal Does not require any specialized instruments, just a standard microfuge Bead format suitable for automation compatibility, please inquire On-Bead digestion for LC-MS analysis, or optional elution for any functional, enzymatic, or immunoassay analysis

NRicher™ Mx employs the use of a bead cocktail, which allows for one, rather than multiple LC-MS analyses to establish dynamic range compression. NRicher™ Mx is thus an all-purpose proteomic enrichment product that can be used for any sample type, from biofluids to tissue lysates. It is compatible with up to 1% non-ionic detergent concentrations. It is particularly useful for membrane proteins. Targets of over 50% of all therapeutic drugs, membrane proteins perform a variety of functions including:

• Receptors which relay information between internal and external environments
• Transport of molecules and ions across the cell membrane
• Enzymatic, and
• Adhesion

NRicher™ Mx beads provide excellent 2-3X enrichment of membrane proteins, most of which are not observable in neat serum. Another example of NRicher™ Mx bead enrichment is α-Synuclein, a biomarker for Parkinsons Disease, observed by NRicher™ Mx, but not observed in the neat serum.