Myristoyl coenzyme A Lithium salt (CAS# 187100-75-0) - 5 mg

Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Appearance: Solid

Formula: C35H63LiN7O17P3S

CAS No.: 187100-75-0

SMILES: O=C(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@]([H])(N2C=NC3=C(N)N=CN=C32)O1)(O)=O)(O)=O)=O)=O)CCCCCCCCCCCCC.[Li].[x]

Shipping: Room temperature

Storage: -20°C, sealed storage, away from moisture and light

Storage in solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture and light)

REFERENCES:

[1]. Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May

24;158(2):107-13.